Benzyne mechanism proceeds,
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Two mechanisms have been proposed for nucleophilic aromatic substitution, one of which involves a benzyne as the intermediate and, therefore, is called benzyne mechanism. ... Thus, for the benzyne mechanism to be operant, the medium must be very strongly basic.
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Two mechanisms have been proposed for nucleophilic aromatic substitution, one of which involves a benzyne as the intermediate and, therefore, is called benzyne mechanism.
eg:
mechanism:
Step 1:
Step 2:
Step 3 :
Step 1 requires a very strong base. Thus, for the benzyne mechanism to be operant, the medium must be very strongly basic.
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