Blood does not clot inside the blood vessel due to the presence of
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heparin is the anticoagulant that prevents blood from clotting inside the blood vessel
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The surface of the cells lining the inside of the blood vessels is smooth. Blood starts clotting when it hits a rough surface. So this prevents that. ... There is a protein called thrombomodulin which binds with another factor called thrombin that acts as an anticoagulant by inactivating clotting factors V and VIII.
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