BRUNO SUFFERED TEMPORARY ________________ UPON HAVING THE POISON KEPT FOR RATS. * 1 point
a)HEART STROKE
b)PARALYTIC STROKE
c)HEAD STROKE
in the poem bond of love
Answers
Answer:
Stroke is a devastating neurovascular disorder that results in damage to neurons and white matter tracts. It has
been previously demonstrated that neuregulin-1 (NRG-1) protects neurons from ischemic injury following
stroke. Here, diffusion tensor imaging (DTI) was utilized to characterize the effects of NRG-1 treatment on
cererbral infarction and integrity of white matter after ischemic insult using a permanent middle celebral artery
occlusion (pMCAo) rat model. In the present study, sixteen Sprague-Dawley rats underwent pMCAo surgery and
received either a single intra-arterial bolus (20 μg/kg) dose of NRG-1 or saline immediately prior to pMCAo. MRI
including T2-weighted imaging and DTI was performed in the first 3 h post stroke, and repeated 48 h later. It is
found that the stroke infarction was significantly reduced in the NRG-1 treated group. Also, NRG-1 prevented the
reduction of fractional anisotropy (FA) in white matter tracts of fornix and corpus callosum (CC), indicating its
protection of CC and fornix white matter bundles from ischemia insult. As a conclusion, the present DTI results
demonstrate that NRG-1 has significantly neuroprotective effects in both cerebral cortex and white matter in-
cluding corpus callosum and fornix during acute stroke. In particular, NRG-1 is more effective on stroke lesion
with mild ischemia. As CC and fornix white matter bundles play critical roles in transcallosal connectivity and
hippocampal projections respectively in the central nervous system, the findings could provide complementary
information for better understanding the biological mechanism of NRG-1's neuroprotection in ischemic tissues
and neurobehavioral effe