Question

cAMP mediated 'Cascade model' of enzyme regulation was proposed by [AllMS 1986]
A) Fischer
B) Sutherland
C) Sumner
D) Koshland

Answer 1

cAMP mediated 'Cascade model' of enzyme regulation was proposed by
A) Fischer

Answer 2

Answer: Sutherland

Explanation:

cAMP-dependent pathway model  is generally known as the Adenyl Cyclase Pathway. It is a G-PCR triggered (G-protein coupled receptor-triggered)signaling cascade which is used in the cell communication.

The nobel prize was given to Earl Sutherland for his discovery. Ted Rall was his college who helped him in his discovery. cAMP is considered as the secondary messenger along with Calcium inons( Ca2+).

The mechanism of action of epinephrine during Glycogenesis was describe by him which demands cAMP as secondary messenger.