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Regulation of distal nephron acid-base transport is crucial, because this is the final site of control of urine composition. The distal tubule responds to systemic acidosis in a teleologically appropriate direction of increased H+ secretion and new HCO3− generation
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the buffer systems functioning in blood plasma include plasma proteins phosphate and biocarbonate and carbonic acid buffer the kidneys help control acid- base balance by excreting hydrogen ions and generating bicorbonate that helps maintain blood plasma pH within a normal range
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