Question

Can anyone help me to write this mechanism of action of fluoroquinolones antibiotic in short?
Mechanism of action: The FQs inhibit the enzyme bacterial DNA gyrase (primarily active in gram negative bacteria), which nicks doublestranded DNA, introduces negative supercoils and then reseals the nicked ends. This is necessary to prevent excessive positive supercoiling of the strands when they separate to permit replication or transcription. The DNA gyrase consists of two A and two B subunits: The A subunit carries out nicking of DNA, B subunit introduces negative supercoils and then A subunit reseals the strands. FQs bind to A subunit with high affinity and interfere with its strand cutting and resealing function. In gram-positive bacteria the major target of FQ action is a similar enzyme topoisomerase IV which nicks and separates daughter DNA strands after DNA replication. Greater affinity for topoisomerase IV may confer higher potency against gram-positive bacteria. The bactericidal action probably results from digestion of DNA by exonucleases whose production is signalled by the damaged DNA. In place of DNA gyrase or topoisomerase IV, the mammalian cells possess an enzyme topoisomerase II (that also removes positive supercoils) which has very low affinity for FQs— hence the low toxicity to host cells. ​

Answer 1

Explanation:

A landmass surrounded by water on three sides or a three location is called peninsula

Answer 2

Answer:

yes it's so easy you should just equalaute this so the answer is Dna