Question

can you explain three ways that transcriptional repression can occur. please use some example. (200word)​

Answer 1

• Answer:
• Key points:
• Transcription factors are proteins that help turn specific genes "on" or "off" by binding to nearby DNA.
• Transcription factors that are activators boost a gene's transcription. Repressors decrease transcription.
• Groups of transcription factor binding sites called enhancers and silencers can turn a gene on/off in specific parts of the body.
• Transcription factors allow cells to perform logic operations and combine different sources of information to "decide" whether to express a gene.
• Explanation:

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Answer 2

Answer:

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Explanation:

• Regulation of gene expression by transcriptional repression represents an ancient and conserved mechanism that manifests itself in diverse forms. Here we summarize conserved pathways for transcriptional repression prevalent throughout all forms of life, as well as indirect mechanisms that appear to have originated in eukaryotes, consistent with their unique chromatin environment.
• The direct interactions between transcriptional repressors and core machinery in bacteria and archaea are sufficient to generate a sophisticated suite of mechanisms that provide flexible control. These direct interactions contrast with the activity of corepressors, which provide an additional regulatory control in eukaryotes. Their modulation of chromatin structure represents an indirect pathway to downregulate transcription, and their diversity and modulation provides additional complexity suited to the requirements of elaborate eukaryotic repression patterns.

• New findings indicate that corepressors are not necessarily restricted to generating a single stereotypic output, but can rather exhibit diverse functional responses depending on the context in which they are recruited, providing a hitherto unsuspected additional source of diversity in transcriptional control. Mechanisms within eukaryotes appear to be highly conserved, with novel aspects chiefly represented by addition of lineage- specific corepressor scaffolds that provide additional opportunities for recruiting the same core machinery.