Question

Carl de luca 2008 insulin resistance (ir) is a defining factor in the development of metabolic syndrome

Answer 1

Insulin resistance is a characteristic feature of most patients with type 2 diabetes mellitus (T2DM) and is one of the defining clinical features in the metabolic syndrome ...

Answer 2

While in adipose tissue and hepatic tissue, IL6 is shown to be a pro-inflammatory adipokine. It increases insulin resistance by up-regulating suppressor of cytokine signalling 3 (SOCS3), which, in turn, impairs insulin-induced insulin receptor and IRS1 phosphorylation (Senn et al. 2002, 2003, Rotter et al. 2003).