Cell plasticity and transdifferentiation
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One of the most contentious issues in biology today concerns the existence of stem cell plasticity. The term “plasticity” refers to the capacity of tissue‐derived stem cells to exhibit a phenotypic potential that extends beyond the differentiated cell phenotypes of their resident tissue. Although evidence of stem cell plasticity has been reported by multiple laboratories, other scientists have not found the data persuasive and have remained skeptical about these new findings. This review will provide an overview of the stem cell plasticity controversy. We will examine many of the major objections that have been made to challenge the stem cell plasticity data.
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