Centrosome and centriole division are controlled by which cyclin dependent kinase
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Cdk2 is known to associate with both cyclin E and cyclin A, although it is predominantly found associated with cyclin E in Xenopus early development (33). ... Thus far, we have shown that inhibition or depletion of cyclin/cdk2, the major interphase cell cycle kinase, prevents centrosome duplication.
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Injection of the cdk (cyclin-dependent kinase) inhibitor p21 into one blastomere of a dividing embryo blocks centrosome duplication in that blastomere; the related cdk inhibitor p27 has a similar effect. An in vitro system using Xenopus extracts carries out separation of the paired centrioles within the centrosome.
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