certain microorganisms and their product cause ..... of B cells
Answers
Answer:
destruction..............
Introduction
1.1. A brief history on the B-cell discovery
The immune response comprises cellular and humoral elements; among the cellular elements, macrophages were the first cells to be described by Metchnikoff in the year 1889 [1]. Almost simultaneously with Metchnikoff findings, began the recognition of one of the primordial elements of the specific humoral response: the antibodies. Von Bering and Kitasato in 1880 present their first work on serotherapy, showing that in the serum of animals immunized with diphtheria or tetanus toxins, there were specific elements of recognition for these toxins and that their use in patients conferred protection [2]. Later, Phlizalix and Calmette groups independently produce antisera against snake venoms [3], confirming the relevance of specific serum elements for the protective response. In those days, histological studies on organs of experimental animals subjected to immunization processes suggested that lymphoid organs were sites likely responsible for the synthesis of the serum elements responsible for protection against toxins and poisons [4]. Tisselius and Kabat in the 1930s demonstrated by electrophoretic techniques that humoral elements responsible for the serological protective response against toxins and poisons belong to the serum gamma globulin fraction [5]. Some years later, in the 1940s, ex vivo culture of plasma cells from the spleen of hyperimmune animals was achieved, and it was observed that, even in culture, the plasma cells were still producing the specific antibodies [6]. Later, the development and application of fluorescence techniques allowed the identification of antibodies in situ,