Question

Chemical reviews streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis

Answer 1

The process of protein translation and, in particular, the macromolecular ribozyme that is the ribosome were among the first recognized molecular targets for antibiotics. A great number of these antibiotics have since found clinical use or therapeutic promise over the past 50 years (Table 1). Translation and the ribosome remain outstanding drug targets with numerous efforts directed toward further mining the potential of this ribozyme and associated activities in drug design..