Chloride shift is
1) The diffusion of chloride ions from plasma into the erythrocytes
2) The diffusion of chloride ions from erythrocytes to plasma
3) The diffusion of Na into the RBC from plasma in response to Cl-diffusion
4) The diffusion of chloride ions from plasma into the leucocytes
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Chloride shift (also known as the Hamburger phenomenon or lineas phenomenon, named after Hartog Jakob Hamburger) is a process which occurs in a cardiovascular system and refers to the exchange of bicarbonate (HCO3−) and chloride (Cl−) across the membrane of red blood cells (RBCs).[1]
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