chloroxylenol is derivative of
Answers
Answer:
Chloroxylenol, or parachlorometaxylenol, a synthetic halogen-substituted phenol derivative, and triclosan, a diphenyl ether, do not appear to offer any advantages over the more commonly used antiseptics in veterinary medicine.
Explanation:
In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016
Drug administration
Drug overdose
There have been many cases of intoxication with oral Dettol liquid, a widespread household disinfectant that contains chloroxylenol 4.8%, pine oil, and isopropyl alcohol [4–8]. Dettol was involved in 10% of hospital admissions related to self-poisoning in Hong Kong. In a retrospective study of 67 cases, serious complications were relatively common (8%) and these included aspiration of Dettol with gastric contents, resulting in pneumonia, cardiopulmonary arrest, bronchospasm, adult respiratory distress syndrome, and severe laryngeal edema with upper airway obstruction. Of 89 patients, five developed minor hematemesis, in the form of coffee-colored or blood-stained vomitus [6]. One patient had a gastroscopy performed on the day after admission, which showed signs of chemical burns in the esophagus and stomach. Gastroscopy in another patient on day 11, done to rule out an esophageal stricture, showed no abnormality. All patients with hematemesis recovered completely. The authors suggest that upper gastrointestinal hemorrhage after Dettol ingestion tends to be mild and self-limiting. Gastroscopy, which may increase the risk of aspiration in patients with impaired consciousness, is not required unless other causes of gastrointestinal bleeding are suspected. Furthermore, Dettol poisoning can be associated with an increased risk of aspiration, possibly caused by the use of gastrointestinal lavage in 88% of the patients and vomiting in 62% [6,7].
Of 121 patients who ingested Dettol 200–500 ml, three developed renal impairment, as evidenced by raised plasma urea and creatinine [7]. Two of these patients also had serious complications, including aspiration leading to pneumonia and adult respiratory distress syndrome; one died. Renal impairment only appears to be observed when relatively large amounts of Dettol are ingested