Question

choroidal neovascular membrane differential diagnosis

Answer 1

acquired degeneration of the retina that causes significant central visual impairment through a combination of non-neovascular (drusen and retinal pigment epithelium abnormalities), and neovascular derangement (choroidal neovascular membrane formation). Advanced disease may involve focal areas of retinal pigment epithelium (RPE) loss, subretinal or sub-RPE hemorrhage or serous fluid, as well as subretinal fibrosis. A genetic underpinning is inferred from its predilection to those of European ancestry, although environmental, nutritional, and developmental (ie., aging) processes interact to affect the degeneration observed in the macula. Newly implicated biochemical pathways combined with a paucity of treatment options for the majority of ARMD (i.e.,dry ARMD) has created fertile ground for novel therapeutics.