chromosomal aberration
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A chromosomal disorder, anomaly, aberration, or mutation is a missing, extra, or irregular portion of chromosomal DNA. It can be from a typical number of chromosomes or a structural abnormality in one or more chromosomes.
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A mutation that is responsible for the visible changes in the structure of the chromosome, is known as "Chromosomal aberration".
The aberrations in chromosome are as follows :-
- Deletion or Deficiency - This refers to the loss of genes due to the breaking down of gene fragments.
- Duplication - This refers to the inclusion of the extra parts of the chromosomes due to which, some genes may get represented twice.
- Inversion - In this aberration, a piece of chromosome gets removed and then, gets rejoined in reverse order.
- Pericentric Inversion - In this aberration, the Centromere lies within the inverted region of the chromosome.
- Paracentric Inversion - In this aberration, the Centromere lies outside the inverted region of the chromosome.
- Translocation - This refers to the mutual exchange (reciprocal) of the chromosome segments between the non-homologous chromosomes.
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