Chronic lymphocytic leukemia patients often harbor nonsense mutations in their spliceosome machinery. Describe how this mutation of the spliceosome would change the final location and sequence of a pre-mRNA.
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Nonsense spliceosome mutations would eliminate the splicing step of mRNA processing, so the mature mRNAs would retain their introns and be perfectly complementary to the entire DNA template sequence. However, the mRNAs would still undergo addition of the 5' cap and poly-A tail, and therefore each has the potential to be exported to the cytoplasm for translation.
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lilaliang:
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because I research first and then asked the question:) I just wanted another another answer to make sure I understand it.
i did not know the answer, I thought you have asked question because you did not know so, i searched it and found the answer so i copy and pasted. i mean you will understand
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