Question

Chronic mild stress effect on brain bdnf levels in depression

Answer 1

hey mate...

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Structural abnormalities, particularly in the hippocampus, are observed in brain structures of depressed patients. The correction of these abnormalities with treatment suggests that major depressive disorders may be associated with a decrease in cellular elasticity and structural plasticity, and antidepressant treatments may provide benefits by treating these disorders. In this study, we aimed to investigate the effect of venlafaxine treatment on the brain-derived neurotrophic factor (BDNF) and BDNF levels in the hippocampus of depression-induced rats by using the chronic mild stress (CMS) model. In this study, 30 eight-week-old, Wistar albino male rats were divided into three groups. The first group received venlafaxine (20 mg/kg) with CMS, the second group a placebo with CMS, and the third group only a placebo (n = 10) for four weeks. At the end of the four week period, BDNF levels in hippocampus tissues were measured. The measurements showed that the BDNF levels of the depressed group were significantly lower than those of the control group. In our study, the hippocampal BDNF levels of the venlafaxine administered group were similar to those of the control group and significantly higher than those of the depressed group. In conclusion, these findings show that the BDNF, which has an important function in neuroplasticity, plays a role in depression pathophysiology, and venlafaxine prevents the BDNF decrease observed in depression. This latter result supports the view that depression treatment prevents the long-term complications of the disorder.

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Answer 2

ram ram ...

here is your answer mate...

Depression induced by stress is affected by sex, age and hormonal status of the animal and also by duration and type of the stressors. Moreover, higher prevalence of depression and comorbidities in women than men implies the need to include the sex variable in studies on animal models of depression. The present study was therefore initiated to evaluate the effect of sex and ovarian hormones on depression-like phenotypes in mice exposed to a 21-day Chronic Variable Mild Stress (CVMS) paradigm. Adult male, intact female and, ovariectomized (OVX) female mice exposed to CVMS displayed despair behavior, a depression-like phenotype, in all the groups.