Compare and contrast between shortgun sequencing and clone by clone sequencing
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By removing the mapping stages, whole genome shotgun sequencing is a much faster process than clone-by-clone sequencing. Whole genome shotgun sequencing uses a fraction of the DNA that clone-by-clone sequencing needs. ... Shotgun sequencing is much faster and less expensive than methods requiring a genetic map.
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During clone-by-clone sequencing, a map of each chromosome of the genome is made before the DNA is split up into fragments ready for sequencing. ... Each fragment is 500 base pairs long so that they are a more manageable size for sequencing. These fragments are put into a vector? that has a known DNA sequence.
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