Question

Compare discontinuous and semi discontinuous mode of replication

Answer 1

Semi-discontinuous nature of replication is attributed to the fact that one strand is replicated continuously whereas the other strand in discontinuous fashion. The continuous synthesis here means that the replication only needs one primer, and the replication occurs till the termination site. This strand is called Leading strand. On the counterpart, the discontinuous strand, also called Lagging strand, will have the formation of Okazaki fragments.
The Trombone model can well explain the semi-discontinuous replication. It gives an explanation how the Polymerase III holoenzyme manage to replicate in the opposite direction without falling off from the strand.
The DNA pol III holoenzyme has 3 Polymerase III core enzymes. Two DNA pol III core enzyme is dedicated to Lagging strand (as the replication is slow) and one is devoted to Leading strand.


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Answer 2

Answer:

However, now it is known that DNA synthesis is continuous on one strand and discontinuous on the other strand (Fig. 26.6). ... This behaviour where the leading strand is synthesized continuously and the lagging strand is synthesized discontinuously is called semi-discontinuous replication.