Question

Complementary pathways required for t cell

Answer 1

T cells and antigen-presenting cells generates complement proteins.  

Immune cell-derived alternative pathway complement components activate rapidly giving local but not systemic, production of C3a and C5a.  

The complement T cell and APC activation works for T cell variations for their survival.  

Deficiency attenuates T cell mediated autoimmunity and delays allograft rejection in mouse.