Complete the analogy
FSH: Development of oocyte : :LH:________
Answers
This FSH will circulate in blood, and combine with FSH receptor in granulosa cells. At this time, they are metabolically inactive, they are flat. There is only one layer surrounding granulosa.
FSH binding to receptor stimulates more receptor to be expressed, so granulosa cells exhibit more FSH receptor, making granulosa cells more sensitive.
Pituitary FSH→↑in iFSH R' on granulosa cells→follicles more sensitive to FSH→↑# of granulosa cells→granulosa cells to produce estrogen (main form-estradiol E2)→↑E2 secretion to follicular fluid and blood
Towards the end of the phase:
FSH +E2→↑LH R' on granulosa cells of graafian follicle
Rapid ↑in E2 from granulosa cells →↑frequency of hypothalamic GnRH puleses →↑LH secretion
This FSH will circulate in blood, and combine with FSH receptor in granulosa cells. At this time, they are metabolically inactive, they are flat. There is only one layer surrounding granulosa.
FSH binding to receptor stimulates more receptor to be expressed, so granulosa cells exhibit more FSH receptor, making granulosa cells more sensitive.
Pituitary FSH→↑in iFSH R' on granulosa cells→follicles more sensitive to FSH→↑# of granulosa cells→granulosa cells to produce estrogen (main form-estradiol E2)→↑E2 secretion to follicular fluid and blood
Towards the end of the phase:
FSH +E2→↑LH R' on granulosa cells of graafian follicle
Rapid ↑in E2 from granulosa cells →↑frequency of hypothalamic GnRH puleses →↑LH secretion
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