Question

Comt inhibitors restrict the action of enzymes when converts levodopa to dopamine

Answer 1

Levodopa is absorbed from the small intestine by the active transport mechanism for large neutral amino acids. ... Since the DOPA decarboxylase inhibitor does not cross the blood–brain barrier, it has no effect on the required conversion of levodopa to dopamine by DOPA decarboxylase within the central nervous system (CNS).