Question

Consider gene rearrangement of the heavy chain gene. the rss downstream of the vh regions has a two-turn sequence. the single-stranded hairpin loop generated during deletional joining will contain nucleotides that were originally part of the

Answer 1

V(D)J recombination is the unique mechanism of genetic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It involves somatic recombination, and results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors found on B cells and T cells, respectively. The process is a defining feature of the adaptive immune system and its development was a key event in the evolution of jawed vertebrates.

Answer 2

Explanation:

Virtually any substance can elicit an antibody response. Furthermore, the response even to a simple antigen bearing a single antigenic determinant is diverse, comprising many different antibody molecules each with a unique affinity, or binding strength, for the antigen and a subtly different specificity. The total number of antibody specificities available to an individual is known as the antibody repertoire, or immunoglobulin repertoire, and in humans is at least 1011, perhaps many more. The number of antibody specificities present at any one time is, however, limited by the total number of B cells in an individual, as well as by each individual's encounters with antigens.

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