Question

Continued neuromuscular blockade with which group of anesthesia

Answer 1

Neuromuscular blocking drugs (NMBDs) act at several sites at the neuromuscular junction, but their main effects are as agonists and antagonists at postjunctional nicotinic receptors.

Succinylcholine is the only available depolarizing NMBD; it has several undesirable side-effects.

Less potent non-depolarizing NMBDs have a more rapid onset of action, comparable with succinylcholine.

Aminosteroid NMBDs depend on organ function for metabolism and excretion. They can have active metabolites.

Benzylisoquinolinium compounds undergo organ-independent degradation but tend to release histamine.

A short-acting non-depolarizing NMBD with a rapid onset and short duration of effect is required to replace succinylcholine