convert p nitrobenzoic acid to p nitroaniline
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Submitted by O. Kamm and A. O. Matthews.
Checked by H. T. Clarke and W. W. Hartman.
1. Procedure
In a 5-l. round-bottomed flask, fitted with a mechanical stirrer, are placed 680 g. (2.3 moles) of sodium dichromate, 1500 cc. of water, and 230 g. (1.7 moles) of p-nitrotoluene. Stirring is started, and 1700 g. of concentrated sulfuric acid is allowed to flow in during about thirty minutes (Note 1). The heat of dilution of the sulfuric acid will cause the nitrotoluene to melt, and rapid oxidation will soon take place. The last half of the sulfuric acid must be added gradually, in order to prevent too violent a reaction. Since a small amount of nitrotoluene is volatilized, it is advisable to carry on this work under a hood.
After the sulfuric acid has been added and the spontaneous heating of the reaction mixture has subsided, the mixture is heated to gentle boiling for about one-half hour (Note 2). When the reaction mixture has cooled, 2 l. of water is added, the cooled solution is filtered through a cloth filter, and the product washed with about 1 l. of water. In order to remove the chromium salts as completely as possible, the crude p-nitrobenzoic acid is warmed on the water bath and agitated with 1 l. of dilute (5 per cent) sulfuric acid solution (Note 3). After cooling, the product is again filtered. It is then dissolved in 5 per cent sodium hydroxide solution, filtered from any chromium hydroxide remaining, and also from unchanged nitrotoluene. The filtrate, which should be light yellow or greenish in color, is acidified with dilute sulfuric acid, with stirring. It is usually preferable to run the alkaline solution into the dilute sulfuric acid, rather than to use the reverse procedure, for the precipitation of the nitro acid (Note 4). The precipitated product is filtered with suction, washed thoroughly, and dried. The product should have only a light lemon color. The yield is 230–240 g. (82–86 per cent of the theoretical amount).
For a product of special purity, crystallization from benzene is advisable. For most purposes, however, the nitrobenzoic acid may be used without crystallization, since its melting point is found to be within 2° of the correct value of 238°.
Checked by H. T. Clarke and W. W. Hartman.
1. Procedure
In a 5-l. round-bottomed flask, fitted with a mechanical stirrer, are placed 680 g. (2.3 moles) of sodium dichromate, 1500 cc. of water, and 230 g. (1.7 moles) of p-nitrotoluene. Stirring is started, and 1700 g. of concentrated sulfuric acid is allowed to flow in during about thirty minutes (Note 1). The heat of dilution of the sulfuric acid will cause the nitrotoluene to melt, and rapid oxidation will soon take place. The last half of the sulfuric acid must be added gradually, in order to prevent too violent a reaction. Since a small amount of nitrotoluene is volatilized, it is advisable to carry on this work under a hood.
After the sulfuric acid has been added and the spontaneous heating of the reaction mixture has subsided, the mixture is heated to gentle boiling for about one-half hour (Note 2). When the reaction mixture has cooled, 2 l. of water is added, the cooled solution is filtered through a cloth filter, and the product washed with about 1 l. of water. In order to remove the chromium salts as completely as possible, the crude p-nitrobenzoic acid is warmed on the water bath and agitated with 1 l. of dilute (5 per cent) sulfuric acid solution (Note 3). After cooling, the product is again filtered. It is then dissolved in 5 per cent sodium hydroxide solution, filtered from any chromium hydroxide remaining, and also from unchanged nitrotoluene. The filtrate, which should be light yellow or greenish in color, is acidified with dilute sulfuric acid, with stirring. It is usually preferable to run the alkaline solution into the dilute sulfuric acid, rather than to use the reverse procedure, for the precipitation of the nitro acid (Note 4). The precipitated product is filtered with suction, washed thoroughly, and dried. The product should have only a light lemon color. The yield is 230–240 g. (82–86 per cent of the theoretical amount).
For a product of special purity, crystallization from benzene is advisable. For most purposes, however, the nitrobenzoic acid may be used without crystallization, since its melting point is found to be within 2° of the correct value of 238°.
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