Corona virus is a RNA virus , its genome was sequenced within *
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Explanation:
Coronaviruses possess the largest genomes of all RNA viruses, consisting of about 30 kb. As a result of their unique mechanism of viral replication, coronaviruses have a high frequency of recombination.
Coronaviruses possess the largest genomes of all RNA viruses, consisting of about 30 kb. As a result of their unique mechanism of viral replication, coronaviruses have a high frequency of recombination.Based on genotypic and serological characterization, coronaviruses were divided into three distinct groups, with human coronavirus 229E (HCoV-229E) being a group 1 coronavirus and human coronavirus OC43 (HCoV-OC43) being a group 2 coronavirus (16). They account for 5 to 30% of human respiratory tract infections. In late 2002 and 2003, the epidemic caused by SARS-CoV affected more than 8,000 people with 750 deaths (23-25, 44, 45, 51). We have also reported the isolation of SARS-CoV-like viruses from Himalayan palm civets, which suggested that animals could be the reservoir for the ancestor of SARS-CoV (9). On the basis of genome analysis, SARS-CoV belonged to a fourth coronavirus group or alternatively was a distant relative of group 2 coronaviruses (4, 20, 28, 31, 48). Recently, a novel group 1 human coronavirus associated with respiratory tract infections, HCoV-NL63, was discovered, and its genome was sequenced (37).
Coronaviruses possess the largest genomes of all RNA viruses, consisting of about 30 kb. As a result of their unique mechanism of viral replication, coronaviruses have a high frequency of recombination.Based on genotypic and serological characterization, coronaviruses were divided into three distinct groups, with human coronavirus 229E (HCoV-229E) being a group 1 coronavirus and human coronavirus OC43 (HCoV-OC43) being a group 2 coronavirus (16). They account for 5 to 30% of human respiratory tract infections. In late 2002 and 2003, the epidemic caused by SARS-CoV affected more than 8,000 people with 750 deaths (23-25, 44, 45, 51). We have also reported the isolation of SARS-CoV-like viruses from Himalayan palm civets, which suggested that animals could be the reservoir for the ancestor of SARS-CoV (9). On the basis of genome analysis, SARS-CoV belonged to a fourth coronavirus group or alternatively was a distant relative of group 2 coronaviruses (4, 20, 28, 31, 48). Recently, a novel group 1 human coronavirus associated with respiratory tract infections, HCoV-NL63, was discovered, and its genome was sequenced (37).In this study, we report the discovery of a novel group 2 coronavirus in the nasopharyngeal aspirates (NPAs) of patients with pneumonia. The complete genome of the coronavirus was sequenced and analyzed. Based on the findings of this study, we propose that this new virus be designated coronavirus HKU1 (CoV-HKU1).
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