Question

correct order for a decrease in bioavailability of drugs from various dosage form is...​

Answer 1

Answer:

Correct order for a decrease in bioavailability of drugs from various dosage form is given as follows below

Explanation:

The amount and pace at which the active moiety (drug or metabolite) enters systemic circulation and subsequently reaches the site of action are referred to as bioavailability.

A drug's bioavailability is substantially influenced by the dosage form's characteristics, which are partly dictated by how it was made and designed. Knowing if drug formulations are similar is crucial because variations in bioavailability between different drug formulations may have therapeutic implications.

Chemical equivalency states that drug products have the same active ingredient in the same quantity and adhere to established criteria, although inactive substances may vary. According to bioequivalence, the drug products produce equal drug concentrations in plasma and tissues when administered to the same patient according to the same dose regimen. Clinical equivalent demonstrates that medicinal items have the same therapeutic and negative effects when administered to the same patient under the same dosing regimen.

Therapeutic equivalentity is anticipated for products that are bioequivalent. When patients who have been stabilised on one formulation are offered a nonequivalent alternative, therapeutic nonequivalence (e.g., more side effects, less efficacy) is typically discovered during long-term treatment.

Even when there are discrepancies in bioavailability, therapeutic equivalency is occasionally feasible. For instance, penicillin has a therapeutic index (the ratio of the minimum toxic concentration to the median effective concentration) that is so wide that the mild variations in plasma concentration brought on by the various penicillin products' varying levels of bioavailability typically have no impact on efficacy or safety. Contrarily, bioavailability variations may result in significant therapeutic effects for medications with a narrow therapeutic index.

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