Correlation of histopathological diagnosis and tnm staging in oral squamous cell carcinoma
Answers
Fifty(50) patients with oral squamous cell carcinoma was included in the study. Specimen of 35 non-metastatic tumors were compared with 15 metastatic cases. All of the patients were graded to TNM, Broder's and Anneroth's system. TNM is clinical assessment and Broder's is based on only differentiation of cells. On the other hand, six parameters of Anneroth's gives a detail about the morphology of the tumor, invasion criteria in the host tissue and show its correlation with lymph node metastasis. Scoring system of Annearoth's grading indicates demarcation points of worseness of tumor and signifies the possibility of lymph node metastasis.
Results:
Both Anneroth's(P=0.002) and Broder's grading(P=0.012) have been significant but Anneroth's one is more significant then Broder's.
Conclusion:
Anneroth's classification can be taken as a standerd diagnostic factor and predictive factor of lymph node metastasis.
Keywords: Oral squamous cell carcinoma, malignancy grading system, metastasis
INTRODUCTION
Oral cancer is becoming a pressing problem in the world and the WHO predicts a continuing worldwide increase in the number of patients with oral cancer.[1] According to WHO report in 1983, oral cancer is the most common cancer in South East Asia.[2] In India, the incidence of oral cancer is 30–50% of whole body tumor.[3] In Sri Lanka, it forms 30% of all cancers in males[4] and in Pakistan oral cancer is responsible for one-third of all cancers (WHO, 1984), whereas in the UK and USA, oral cancer accounts for only 2% of all malignancies.[5] In Bangladesh, according to Shaheed and Molla, oral cancer accounts for 20% of the whole body malignancy.[6] 90% of oral cancers are squamous cell carcinoma.
Explanation:
Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. Like other types of cancer, carcinomas are abnormal cells that divide without control. They are able to spread to other parts of the body, but don't always.