Question

Cytosolic delivery of proteins by bioreversible esterication

Answer 1

The esterified protein entered the cytosol by traversing the plasma membrane directly, like a small-molecule prodrug. As with prodrugs, the nascent esters are substrates for endogenous esterases, which regenerate native protein.

Answer 2

Cloaking its carboxyl groups with a hydrophobic moiety is shown to enable a protein to enter the cytosol of a mammalian cell. The esterified protein entered the cytosol by traversing the plasma membrane directly, like a small-molecule prodrug.

hope it helps..