Question

Defination of coagulation.

Answer 1

the action or process of a liquid, especially blood, changing to a solid or semi-solid state.


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Answer 2

Hey there!

Coagulation is the process by which the blood loses its liquidity becoming a gel, to form a clot. This process potentially leads to hemostasis, that is, the cessation of blood loss from a damaged vessel, followed by repair. The coagulation mechanism involves activation, adhesion and platelet aggregation, together with the deposition and maturation of fibrin. Coagulation disorders are disease states that can cause spontaneous bleeding, bruising, or obstructive coagulation (thrombosis) .

The coagulation mechanism is highly conserved through different species in biology; in all mammals, coagulation involves cellular factors (platelets) and protein factors (coagulation factors) . The system has been extensively studied in humans, a species where it is better understood.

Coagulation begins almost instantaneously after a wound damages the endothelium of a blood vessel. The exposure of blood to the space beneath the endothelium initiates two processes: changes in platelets, and exposure of subendothelial tissue factor to plasma factor VII, which ultimately leads to fibrin formation. The platelets immediately form a plug at the site of the injury; This process is called primary hemostasis. Secondary hemostasis occurs simultaneously; Protein coagulation factors beyond factor VII respond in a complex cascade of enzymatic reactions to form fibrin fibers, which strengthen the platelet plug.