define complement system_??
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The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane.
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define complement system_??
Complement System: The complement system is a set of 30 different protein molecules always found in the blood. There are no cells in the system. With an infection, this system of molecules is activated, leading to a sequence of events on the surface of the pathogen that helps to destroy the pathogen and eliminate the infection. The complement system can be activated in two main ways:
- Classical Pathway: The first and most potent way known as Classical Pathway occurs when IgG (or IgM) binds to antigen at the surface of a cell. This exposes the Fc region of the antibody such that the first complement protein (C1) binds.
- Alternate Pathway: The second means of activation known as Alternate Pathway is part of the natural (innate) immune response. (.e. neither antibodies nor T cell receptors are involved.) Here certain polysaccharides found on the surface of bacteria activate the system. This can occur immediately and does not require prior exposure to the molecules.
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