define denaturarion of protein
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ᴅᴇɴᴀᴛᴜʀᴀᴛɪᴏɴ, ɪɴ ʙɪᴏʟᴏɢʏ, ᴘʀᴏᴄᴇss ᴍᴏᴅɪғʏɪɴɢ ᴛʜᴇ ᴍᴏʟᴇᴄᴜʟᴀʀ sᴛʀᴜᴄᴛᴜʀᴇ ᴏғ ᴀ ᴘʀᴏᴛᴇɪɴ. ᴅᴇɴᴀᴛᴜʀᴀᴛɪᴏɴ ɪɴᴠᴏʟᴠᴇs ᴛʜᴇ ʙʀᴇᴀᴋɪɴɢ ᴏғ ᴍᴀɴʏ ᴏғ ᴛʜᴇ ᴡᴇᴀᴋ ʟɪɴᴋᴀɢᴇs, ᴏʀ ʙᴏɴᴅs (ᴇ.ɢ., ʜʏᴅʀᴏɢᴇɴ ʙᴏɴᴅs), ᴡɪᴛʜɪɴ ᴀ ᴘʀᴏᴛᴇɪɴ ᴍᴏʟᴇᴄᴜʟᴇ ᴛʜᴀᴛ ᴀʀᴇ ʀᴇsᴘᴏɴsɪʙʟᴇ ғᴏʀ ᴛʜᴇ ʜɪɢʜʟʏ ᴏʀᴅᴇʀᴇᴅ sᴛʀᴜᴄᴛᴜʀᴇ ᴏғ ᴛʜᴇ ᴘʀᴏᴛᴇɪɴ ɪɴ ɪᴛs ɴᴀᴛᴜʀᴀʟ (ɴᴀᴛɪᴠᴇ) sᴛᴀᴛᴇ. ᴅᴇɴᴀᴛᴜʀᴇᴅ ᴘʀᴏᴛᴇɪɴs ʜᴀᴠᴇ ᴀ ʟᴏᴏsᴇʀ, ᴍᴏʀᴇ ʀᴀɴᴅᴏᴍ sᴛʀᴜᴄᴛᴜʀᴇ; ᴍᴏsᴛ ᴀʀᴇ ɪɴsᴏʟᴜʙʟᴇ.
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Denaturation involves the breaking of many of the weak linkages, or bonds (e.g., hydrogen bonds), within a protein molecule that are responsible for the highly ordered structure of the protein in its natural (native) state. ... Denatured proteins have a looser, more random structure; most are insoluble.
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