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A generic drug is a medication created to be the same as an existing approved brand-name drug in dosage form, safety, strength, route of administration, quality, and performance characteristics. A generic medicine works in the same way and provides the same clinical benefit as its brand-name version.
According to the FDA, all drugs, including brand name drugs and generic drugs, must work well and be safe. Generic drugs use the same active ingredients as their brand-name counterparts and, therefore, have the same risks and benefits. About half of all generic drugs are made by brand name companies.
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Answer:
There are two ways generic drugs are used: generic substitution and therapeutic interchange.
Generic substitution means the drug is the equivalent to a brand name on a molecular level. “In terms of effectiveness and quality they are the same, and the FDA has certified both are equal,” says Dr. Niteesh K. Choudhry, assistant professor of medicine at Harvard Medical School. Dr. Choudhry’s research focuses on strategies to improve health care quality and reduce spending. An example is the cholesterol drug Lipitor and the generic version atorvastatin.
Therapeutic interchange is slightly different. The generic is a medical substitute that is molecular related, but not exactly the same. “It is like the difference between a Coke and a store brand cola,” says Dr. Choudhry. Therapeutic interchange is often used for name brands that do not yet have a generic substitution because the brand name patent still exists.
Are therapeutic interchange drugs just as effective as brand names? For the most part, yes, says Dr. Choudhry. “It depends on the drug, what it is designed to treat, and the person, but it often is equally effective. Of course, the downside is they are not 100% guaranteed to work.”
However, most research tends to support the effectiveness of both types of generic drugs. A 2015 report published in the Jan. 5, 2016 issue of the Annals of Internal Medicine advocated the greater use of generic drugs, citing research that supports its overall equality with brand-name counterparts as well as its valuable cost-savings.