define Hoffman's bromamide reaction?
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When an amide is treated with bromine in an aqueous or ethanolic solution of sodium hydroxide, degradation of amide takes place leading to the formation of primary amine. This reaction involving degradation of amide and is popularly known as Hoffmann bromamide degradation reaction. The primary amine thus formed contains one carbon less than the number of carbon atoms in that amide.
RCONH2 +Br2 + 4NaOH R-NH2 + Na2CO3 + 2NaBr + 2H2O
Hope it helps you !
When an amide is treated with bromine in an aqueous or ethanolic solution of sodium hydroxide, degradation of amide takes place leading to the formation of primary amine. This reaction involving degradation of amide and is popularly known as Hoffmann bromamide degradation reaction. The primary amine thus formed contains one carbon less than the number of carbon atoms in that amide.
RCONH2 +Br2 + 4NaOH R-NH2 + Na2CO3 + 2NaBr + 2H2O
Hope it helps you !
Answered by
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When an amide is treated with bromine in an aqueous or ethanolic solution of sodium hydroxide, degradation of amide takes place leading to the formation of primary amine. This reaction involving degradation of amide and is popularly known as Hoffmann bromamide degradation reaction. The primary amine thus formed contains one carbon less than the number of carbon atoms in that amide.
RCONH2 +Br2 + 4NaOH
→
R-NH2 + Na2CO3 + 2NaBr + 2H2O
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