define mutation with example
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In: FACTS In the Cell
What is a mutation?
A mutation is a change that occurs in our DNA sequence, either due to mistakes when the DNA is copied or as the result of environmental factors such as UV light and cigarette smoke.
Over a lifetime our DNA? can undergo changes or ‘mutations?’ in the sequence of bases?, A, C, G and T.
This results in changes in the proteins? that are made. This can be a bad or a good thing.
Mutations can occur during DNA replication? if errors are made and not corrected in time.
Mutations can also occur as the result of exposure to environmental factors such as smoking, sunlight and radiation.
Often cells can recognise any potentially mutation-causing damage and repair it before it becomes a fixed mutation.
Mutations contribute to genetic variation? within species?.
Mutations can also be inherited, particularly if they have a positive effect.
For example, the disorder sickle cell anaemia? is caused by a mutation in the gene? that instructs the building of a protein called haemoglobin?. This causes the red blood cells? to become an abnormal, rigid, sickle shape. However, in African populations, having this mutation also protects against malaria?.