Define oxygen dissociation curve why it has sigmoidal pattern
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More molecules bind as the oxygen partial pressure increases until the maximum amount that can be bound is reached. As this limit is approached, very little additional binding occurs and the curve levels out as the hemoglobin becomes saturated with oxygen. Hence the curve has a sigmoidal or S-shape.
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Oxyhaemoglobin dissociation curve is obtained when percentage saturation of haemoglobin with O2 is plotted against the pO2.
At normal condition this curve is sigmoid and normal.
By increasing the concentration of CO2 ,the curve shifts towards right side.
By decreasing concentration Co2 the curve shifts towards left side.In this way the graph forms sigmoidal pattern.
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