Define Progerin in detail
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Progerin is one of biomarkers, which is used in studies on natural aging. This protein is expressed as a mutant form of the LMNA gene. Because of that it causes many defects in the area of the nuclear envelope. It also influences a level of reactive oxygen species and antioxidant enzymes.
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Progerin (P02545-6) is a truncated version of the lamin A protein involved in the pathology of Hutchinson–Gilford progeria syndrome. ... Progerin increases the frequency of unrepaired double-strand breaks in DNA following exposure to ionizing radiation.
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