delayed type of hypersensitivity
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Type 4 hypersensitivity is often calleddelayed type hypersensitivity as the reaction takes several days to develop. Unlike the other types, it is not antibody-mediated but rather is a typeof cell-mediated response.
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Hypersensitivity means that the body responds to a particular substance (called allergens) in an exaggerated fashion, where it does not happen in normal circumstances. There are 4 types of hypersensitivity reaction, type I, II, III and IV. They are different in terms of the disease manifestation and pathological processes. However, only type IV hypersensitivity reaction will be discussed here.
Type IV hypersensitivity reaction is also called delayed type hypersensitivity reaction because it takes 2 to 3 days for the reaction to develop after exposure to the particular substance.
Type IV hypersensitivity reaction can occur in many parts of the body. Generally, they include:
Skin: Atopic dermatitis
Lungs: Tuberculosis , hypersensitivity pneumonitis , Wegener’s granulomatosis
Pancreas: Type I diabetes mellitus,
or known previously as insulin-dependent diabetes mellitus.
Thyroid: inflammation of the thyroidOther: transplant rejection, leprosy
Type IV hypersensitivity reaction is also called delayed type hypersensitivity reaction because it takes 2 to 3 days for the reaction to develop after exposure to the particular substance.
Type IV hypersensitivity reaction can occur in many parts of the body. Generally, they include:
Skin: Atopic dermatitis
Lungs: Tuberculosis , hypersensitivity pneumonitis , Wegener’s granulomatosis
Pancreas: Type I diabetes mellitus,
or known previously as insulin-dependent diabetes mellitus.
Thyroid: inflammation of the thyroidOther: transplant rejection, leprosy
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