Question

Describe drugs desinging and various approaches of drugs desining

Answer 1

Answer:

Different approaches to drug designing

Computer-aided drug design

   hit identification using virtual screening (structure- or ligand-based design)

   hit-to-lead optimization of affinity and selectivity (structure-based design, QSAR, etc.)

   lead optimization of other pharmaceutical properties while maintaining affinity.

Explanation:

Answer 2

Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.[1] The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques.[2] [3] This type of modeling is sometimes referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design.[3] In addition to small molecules, biopharmaceuticals including peptides[4][5] and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.[6]