Describe general methods for structure elucidation of alkaloids
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The first alkaloids were already isolated in the early 19th century (e.g., morphine, strychnine). Although the methods for identification and structure elucidation have changed a great deal, the methods of isolation used in the last century are still widely used. Originally, pure chemistry, like derivatization and degradation, was used to unravel the often complex structures of alkaloids. The structure elucidation of a well-known alkaloid, such as, for example, strychnine, took almost 140 years after its first isolation by Pelletier and Caventou in 1818.
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