Question

describe mechanism of extravsastion. explain in 200 word.)​

Answer 1

Answer:

Extravasation injury is defined as the damage caused by the efflux of solutions from a vessel into surrounding tissue spaces during intravenous infusion. The damage can extend to involve nerves, tendons, and joints and can continue for months after the initial insult.

Explanation:

Extravasation is the leakage of a fluid out of its container into the surrounding area, especially blood or blood cells from vessels. In the case of inflammation, it refers to the movement of white blood cells from the capillaries to the tissues surrounding them (leukocyte extravasation, also known as diapedesis).

Answer 2

Answer:

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Mechanism Of Extravsastion :-

• In clinical attempts at regeneration, stem cells are often infused into blood vessels feeding the target organ.
• With the hope that the cells will migrate into the surrounding tissue to initiate repair.
• Although such extravasation does indeed occur and results in therapeutic regeneration in humans.
• The mechanisms remain obscure; leukocyte-like diapedesis has been postulated , but with little supporting evidence.
• Here we report a novel cell transmigration mechanism, which we call “active vascular expulsion”.
• Human and rat cardiosphere-derived cells (CDCs; single cells with a size of ~20 μm in diameter) and cardiospheres (CSPs; multi-cellular spheres with a size of ~50 μm in diameter) were derived from human endomyocardial biopsies or Wistar-Kyoto rat hearts, respectively, as described.
• Human bone marrow-derived mesenchymal stem cells (MSC) were obtained from Lonza.

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