Describe the lock and key hypothesis of enzyme action
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The specific action of an enzyme with a single substrate can be explained using a Lock and Key analogy first postulated in 1894 by Emil Fischer. In this analogy, the lock is the enzyme and the key is the substrate. Only the correctly sized key (substrate) fits into the key hole (active site) of the lock (enzyme).
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Lock and key hypothesis proposed specificity between the substrate molecule and the active site of an enzyme. According to this hypothesis, substrate binds to the active site of an enzyme just as a key fits into a specific lock.
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