describe the phenomenon of release and transport of a neurotransmitter
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Transport and release of a neurotransmitter occurs within a synapse. At a chemical synapse, the membranes of the pre- and post-synaptic neurons are separated by a fluid-filled space called synaptic cleft. Chemicals called neurotransmitters are involved in the transmission of impulses at these synapses.
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Release of a neurotransmitter:
- Neurotransmitter-containing vesicles are kept in one of two locations at the terminal of the neuron when it is at rest.
- In regions known as "active zones," a small number of vesicles are positioned along the pre-synaptic membrane.
- Here, neurotransmitters are released.
- The movement of membrane-bound sacs, or synaptic vesicles, toward the presynaptic membrane, is triggered by the arrival of a nerve impulse at the presynaptic terminals.
- These vesicles fuse with the membrane and release a chemical known as a neurotransmitter.
Transport of a neurotransmitter:
- A class of membrane transport proteins known as neurotransmitter transporters spans the cellular membranes of neurons.
- Neurotransmitters are transported across these membranes by them, and they then direct the further transport of those neurotransmitters to particular intracellular regions.
- The neurotransmitter molecules attach to receptor proteins on the postsynaptic cell after diffusing across the synaptic cleft.
- Ion channels in the cell membrane open or close when postsynaptic receptors are activated.
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