Describe the relationship between the ribosome and the ubiquitin-proteosome system.
Answers
Explanation:
I know that ribosomes have two many functions that decoding the message and formation of peptides bonds
Answer:
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Ribosomes are abundance cellular machines and are regulated through multiple degradative pathways.
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Multiple ubiquitin ligases have been identified that can ubiquitylate and promote turnover of either excess unassembled ribosomal proteins or ribosomal proteins that are part of mature ribosomes.
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In yeast, nutrient stress promotes turnover of ribosomes via “ribophagy” in a process that requires the deubiquitylating enzyme Ubp3p.
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In mammalian cells, multiple pathways have been reported to promote ribosomal degradation in response to nutrient and proteotoxic stress.
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This review discusses multiple controversies in the field concerning the pathways used for ribophagy.