Question

Describe the Tri carboxylic acid cycle that occurs in mitochondrial matrix. (Kreb's cycle/ Citric acid cycle).

Answer 1

Tricarboxylic Acid Cycle/Krebs Cycle

TCA cycle was discovered by Hans Krebs in 1940. This cycle is called TCA cycle because initial product is citric acid.

Acetyl CoA combine with OAA ( Oxaloacetic acid) and water to yield citric acid in presence of enzyme citrate synthase to release CoA.

A molecule of glucose produces two molecules of NADH2, 2ATP and two pyruvate while undergoing glycolysis. The two molecules of pyruvate are completely degraded in Krebs cycle to form two molecules of ATP, 8NADH2 and 2FADH2.