Describe the ultrastructure of Mitochondria .
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Mitochondria are bounded by an envelope consisting of two concentric membranes, the outer and inner membranes. The space between the two membranes is called inter-membrane space. A number of invaginations occur in the inner membrane; they are called cristae.
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Mitochondria are commonly between 0.75 and 3 μm² in area[7] but vary considerably in size and structure. Unless specifically stained, they are not visible. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth.[8] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes.[9][10] Mitochondria have been implicated in several human diseases, including mitochondrial disorders,[11] cardiac dysfunction,[12] heart failure[13] and autism.[14]
The number of mitochondria in a cell can vary widely by organism, tissue, and cell type. For instance, red blood cells have no mitochondria, whereas liver cells can have more than 2000.[15][16] The organelle is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, the intermembrane space, the inner membrane, and the cristae and matrix.
Although most of a cell's DNA is contained in the cell nucleus, the mitochondrion has its own independent genome that shows substantial similarity to bacterial genomes.[17] Mitochondrial proteins (proteins transcribed from mitochondrial DNA) vary depending on the tissue and the species. In humans, 615 distinct types of protein have been identified from cardiac mitochondria,[18] whereas in rats, 940 proteins have been reported.[19] The mitochondrial proteome is thought to be dynamically regulated.[20]
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