Described the regulations of parturition
Answers
Answer:
Silvia Vannuccini, Felice Petraglia, in Encyclopedia of Endocrine Diseases (Second Edition), 2019
Abstract
Parturition is a coordinated process of transition from a quiescent myometrium to an active rhythmically contractile state, requiring complex interplay between placental, fetal, and maternal compartments. It involves the synchronization of myometrial activity and structural changes of the cervix, leading to regular coordinated uterine contractions, cervical effacement and dilatation and rupture of membranes. Multiple endocrine, paracrine and autocrine events and overlapping maternal/fetal control mechanisms trigger parturition. In fact, hormonal, neuroendocrine, inflammatory, and immune mechanisms are involve in the activation of labor. Placenta endocrine function contributes to labor onset and progression. Progesterone withdrawal, increased estrogen bioavailability, corticotrophin releasing hormone (CRH) and neuroendocrine mediators rise, increased prostaglandins, and oxytocin are key events in parturition.
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