Question

Despite his.......he had to suffer??

Answer 1

One of the answer can be:

Despite his SEVERAL ATTEMPTS he had to suffer.

Answer 2

Despite his attempt to evade his destiny, he had to suffer what fate had in store for him.

He made many attempts to escape, went to astrologers and soothsayers but in spite of that, what he had been foretold came to pass.

John lost everything in a shipwreck – his family, his fortune, and his health.

He was left all alone in this world.