Difference between aminooxyacetic acid and aminooxyacetic acid hemichloride
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Aminooxyacetic acid, often abbreviated AOAor AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down.[1] Subsequently, the level of GABA is increased in tissues. At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats.[2]
Aminooxyacetic acidNamesIUPAC name
2-(aminooxy)acetic acid
Other names
Carboxymethoxylamine
Hydroxylamineacetic acid
U-7524
Identifiers
CAS Number
645-88-5 
3D model (JSmol)
Interactive image
Interactive image
ChEMBL
ChEMBL347862 
ChemSpider
280 
DrugBank
DB02079 
IUPHAR/BPS
5136
MeSHAminooxyacetic+Acid
PubChem CID
286
UNII
14I68GI3OQ ‹See TfM›
InChI
InChI=1S/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5) 
Key: NQRKYASMKDDGHT-UHFFFAOYSA-N 
InChI=1/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5)
Key: NQRKYASMKDDGHT-UHFFFAOYAB
SMILES
O=C(O)CON
NOCC(O)=O
Properties
Chemical formula
C2H5NO3Molar mass91.066Density1.375 g/cm3Melting point138 °C (280 °F; 411 K)Boiling point326.7 °C (620.1 °F; 599.8 K)HazardsFlash point151 °C (304 °F; 424 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
‹See TfM› (what is ‹See TfM› ?)Infobox references
Aminooxyacetic acid is a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T).[3] It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes
Aminooxyacetic acidNamesIUPAC name
2-(aminooxy)acetic acid
Other names
Carboxymethoxylamine
Hydroxylamineacetic acid
U-7524
Identifiers
CAS Number
645-88-5 
3D model (JSmol)
Interactive image
Interactive image
ChEMBL
ChEMBL347862 
ChemSpider
280 
DrugBank
DB02079 
IUPHAR/BPS
5136
MeSHAminooxyacetic+Acid
PubChem CID
286
UNII
14I68GI3OQ ‹See TfM›
InChI
InChI=1S/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5) 
Key: NQRKYASMKDDGHT-UHFFFAOYSA-N 
InChI=1/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5)
Key: NQRKYASMKDDGHT-UHFFFAOYAB
SMILES
O=C(O)CON
NOCC(O)=O
Properties
Chemical formula
C2H5NO3Molar mass91.066Density1.375 g/cm3Melting point138 °C (280 °F; 411 K)Boiling point326.7 °C (620.1 °F; 599.8 K)HazardsFlash point151 °C (304 °F; 424 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
‹See TfM› (what is ‹See TfM› ?)Infobox references
Aminooxyacetic acid is a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T).[3] It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes
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